Prevalence, Patterns and Peculiarities of Depression among Tuberculosis Patients Attending Directly Observed Treatment Short-course (DOTS) Centers in Lagos State Nigeria
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https://doi.org/10.54536/ajmsi.v3i1.2653Keywords:
Prevalence, Patterns, Peculiarities, Depression, Tuberculosis, DOTS Center, NigeriaAbstract
Tuberculosis (TB) is an infectious disease that is life-threatening to vulnerable populations, and has been reported to be associated with depression. Nigeria is one of the countries with a high TB burden, and with the current economic hardship in Nigeria, people are becoming poorer suggesting more TB patients are more likely to elapse into depression. The aim of this research was to assess the prevalence, patterns and peculiarities of depression among TB patients attending Directly Observed Treatment Short course (DOTS) centers in Lagos State, Nigeria. A descriptive, cross-sectional survey was conducted among 301 TB patients at 8 DOTS centers in Lagos State, Nigeria using a two-stage sampling method. Data was collected using interviewer-administered questionnaires to elicit responses from the TB patients. Patient Health Questionnaire-9 (PHQ-9) was used to determine and assess depression. Data was analyzed using SPSS version 23.0, with the Chi-square test being used to check for the association between socio-demographic characteristics and depression among the respondents. Mean age of the respondents was 35.1±11.7 years. A majority (71.8%) of the respondents were males, 69.1% were Christians, Yorubas were most (52.2%), 88.4% earned ≤N150,000 monthly, and only 1 respondent had no formal education. The prevalence rate of depression among the TB patients was 51.8%. Socio-demographic characteristics like gender (females were more affected), low financial status, and low educational level were associated with depression (p<0.05); unlike age, marital status, ethnicity, employment status, and family setting (p>0.05). Depression among TB patients is real as one in every two TB patients is depressed. Therefore, healthcare workers at DOTS centers should pay adequate attention to signs of depression among their patients.
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References
Adebowale-Tambe, N. (2022). Lagos accounts for 11 percent of Nigeria’s TB cases in 2021 – Official. Premium Times. Available online: http:// www.premiumtimesng.com/regional/ssouth-west/522500-lagos-accounts-for-11-per-cent-of-nigerias-tb-cases-in-2010-official-html?tztc=1
Aniebue, P. N., & Okonkwo, K. O. B. (2007). Prevalence of depressive symptoms amongst pulmonary tuberculosis patients at the University of Nigeria Teaching Hospital, Enugu. International Journal of Medicine and Health Development, 11(2), 120–124.
Anwar, M. S., Dogar, I. A., Sohail, H., Mehdi, Z., Azam, M., & Niaz, O. (2010). Prevalence of depression among tuberculosis patients, A.P.M.C., 4(2), 133-137. Available online: http://applications.emro.who.int/imemrf/Ann_Punjab_Med_Coll/Ann_Punjab_Med_Coll_2010_4_2_133_137.pdf
Baba, A., & Issa, A. D. Y. (2009). Depression comorbidity among patients with tuberculosis in a university teaching hospital outpatient clinic in Nigeria. Mental Health and Family Medicine, 6(3), 133–138.
Bains, N., & Abdijadid, S. (2023). Major depressive disorder. In StatPearls (Ed), Treasure Island (FL). StatPearls Publisher
Cáceres, G., Calderon, R., & Ugarte-Gi, C. (2022). Tuberculosis and comorbidities: treatment challenges in patients with comorbid diabetes mellitus and depression. Therapeutic Advances in Infectious Disease, 9, 1-17. https://doi.org/10.1177/ 2049936122109583.
Dahiya, S., Khichi, S. K., Goel, P. K., Singh, A., & Singh, N. K. (2017). Prevalence of depression among tuberculosis patients. Scholars Journal of Applied Medical Sciences, 5(6C), 2212-2215.
Dasa, T.T., Roba, A. A., Weldegebreal, F., Mesfin, F., Asfaw, A., Mitiku, H., Teklemariam, Z., Geddugol, B. J., Naganuri, M., Befikadu, H., & Tesfaye, E. (2019). Prevalence and associated factors of depression among tuberculosis patients in Eastern Ethiopia. BMC Psychiatry, 19, 82-88.
DeJean, D., Giacomini, M., Vanstone, M., & Brundisini, F. (2013). Patient experiences of depression and anxiety with chronic disease. Ontario Health Technology Assessment Series, 13(16), 1–33.
Duko, B., Bedaso, A., & Ayano, G. (2020). The prevalence of depression among patients with tuberculosis: a systematic review and meta-analysis. Annals of General Psychiatry, 7, 19-30. https://doi.org/10.1186/s12991-020-00281-8.
Ekechi, H. O., Ikwuka, A. O., Udeh, F. C., & Abraham, J. C. (2023)a. Effects of Ethanol Extract of Rauwolfia vomitoria Leaf on Lipid Profile and Cerebellar Histology in Cisplatin-induced Oxidative Stress. British Journal of Medical and Health Research, 10(5), 16-39. https://doi.org/10.5281/zenodo.8042521.
Ekechi, H. O., Ikwuka, A. O., Udeh, F. C., Epete, M. A., & Uche, V. U. (2023)b. Hepatorenal Protective Functions of Coconut Water in Alloxan-Induced Type 1 Diabetes Mellitus. World Journal of Current Medical and Pharmaceutical Research, 5(4), 114-122. https://doi.org/10.37022/wjcmpr.v5i4.276.
Ige, O. M., & Lasebikan, V. O. (2011). Prevalence of depression in tuberculosis patients in comparison with non-tuberculosis family contacts visiting the DOTS clinic in a Nigerian tertiary care hospital and its correlation with disease pattern. Mental Health and Family Medicine, 8(4), 235–241.
Ikwuka, A. O. (2015). Risk factors for the pathogenesis of diabetes mellitus type 2. Materials of 84th Scientific and Practical Conference of Students and Young Scientists with International Participation “Innovations in medicine”, p. 19. Available online: http://www.ifnmu.edu.ua/images/snt/files/konferenciya/Tezu_2015.pdf
Ikwuka, A. O. (2017)a. Dyslipidemia risk severity in patients with diabetes mellitus type 2 and essential hypertension. Journal of the 21st International Medical Congress of Students and Young Scientists, p. 59.
Ikwuka, A. O. (2017)b. Effectiveness of dapagliflozin in patients with diabetes mellitus type 2 and essential hypertension. Book of abstracts of the 7th International Students’ Scientific Conference of Young Medical Researchers, p. 102. Available online: http://www.stn.umed.wroc.pl/files/lm/Accepted_papers.16113.pdf
Ikwuka, A. O. (2017)c. Influence of dyslipidemia in patients with diabetes mellitus type 2 and essential hypertension. The Pharma Innovation Journal, 6(3), 101-103. Available online: http://www.thepharmajournal.com/archives/?year=2017&vol=6&issue=3&part=B
Ikwuka, A. O., & Haman, I. O. (2017)d. Features of kidney damage in patients with diabetes mellitus type 2 and essential hypertension. Journal of 86th Scientific and Practical Conference of Students and Young Scientists with International Participation “Innovations in medicine”, p. 144. Available online: http://www.ifnmu.edu.ua/images/snt/86-konf-tezi%20(1).pdf
Ikwuka, A. O., Virstyuk, N. G., & Luchko, O. R. (2017)e. Features of the functional state of kidneys in patients with diabetes mellitus type 2 and essential arterial hypertension. Materials of scientific-practical conference with international participation “Babenkivski reading”, p. 48.
Ikwuka, A. O. (2018)a. Clinical dynamics in patients with diabetes mellitus type 2 and concomitant essential hypertensive disease treated with dapagliflozin. Journal of the 22nd International Medical Congress of Students and Young Scientists, p. 32.
Ikwuka, A. O. (2018)b. Clinical effectiveness of SGLT-2 inhibitors in patients with diabetes mellitus type 2 and essential hypertensive disease. Endocrine Practice, 24(1), 74. https://doi.org/10.1016/S1530-891X(20)47129-0.
Ikwuka, A. O. (2018)c. Features of kidney damage in patients with arterial hypertension and type 2 diabetes mellitus and optimization of treatment. Specialized Academic Council IFNMU, Available online: http://www.ifnmu.edu.ua/images/zagalna_informacia/spec_vcheni_radi/2017-2019/%D0%9420.601.01/Ikvuka/Avtoreferat.pdf
Ikwuka, A. O., & Paliy, Yu. (2018)d. Structural changes of the left ventricular myocardium in patients with essential arterial hypertension and diabetes mellitus type 2. Abstracts of the 87th Scientific Conference of Students and Young Scientists with International Participation “Innovations in medicine”, p. 25-26. Available online: https://www.ifnmu.edu.ua/images/snt/zaproshennia_eng.pdf
Ikwuka, A. O. (2019)a. Clinical dynamics of nephropathy in patients with diabetes mellitus type 2 and concomitant essential hypertensive disease. Clinical Medicine, 19(2), s39. https://doi.org/10.7861/clinmedicine.19-2-s39.
Ikwuka, A. O. (2019)b. Clinical effectiveness of GLP-1 RAs in patients with metabolic syndrome diseases. Endocrine Practice, 25(1), 104-105. https://doi.org/10.1016/S1530-891X(20)46611-X.
Ikwuka, A. O., & Virstyuk, N. G. (2019)c. Pattern of cardiac remodelling of the left ventricle in patients with essential hypertensive disease and concomitant type 2 diabetes mellitus. Clinical Medicine, 19(3), s92. https://doi.org/10.7861/clinmedicine.19-3-s92.
Ikwuka, A. O., & Virstyuk, N. G. (2021). Influence of SGLT2 inhibitor and A2RB (AT1) on fibrogenesis and heart failure in patients with essential hypertensive disease combined with diabetes mellitus type 2. E-Poster No. 143 of the 44th & 45th Annual General and Scientific Meeting of the West African College of Physicians (WACP), 1 - 3 November, 2021. https://doi.org/10.13140/RG.2.2.26912.87047.
Ikwuka, A. O., & Virstyuk, N. (2022). Prognostic markers of nephropathy in patients with dual metabolic syndrome diseases (essential hypertensive disease and concomitant type 2 diabetes mellitus). Endocrine Practice, 28(5), S65-S66. https://doi.org/10.1016/j.eprac.2022.03.164.
Ikwuka, A. O. (2023)a. Dr. Aloy’s Core Essential Series (DACES) Medical Genetics. 1st Edition. Science and Education Publishing, USA, p. 15. ISBN: 978-1-958293-02-7.
Ikwuka, A. O. (2023)b. Dr. Aloy’s Core Essential Series (DACES) Immunology. 1st Edition. Science and Education Publishing, USA, p. 30. ISBN: 978-978-795-866-7.
Ikwuka, A. O., & Virstyuk, N. (2023)c. Patterns and Influence of Cardio-Metabolic Insufficiency in Patients with Essential Hypertensive Disease and Concomitant Type 2 Diabetes Mellitus. Endocrine Practice, 29(5), S32-S33. https://doi.org/10.1016/j.eprac.2023.03.076.
Ikwuka, A. O., Virstyuk, N. G., Luchko, O. R., & Kobitovych, I. (2023)d. Heterogeneity Of Renal Pathogenicity On The Background Of Asymptomatic Hyperuricemia In Patients With Dual Metabolic Syndrome Diseases (Essential Hypertensive Disease and Type 2 Diabetes Mellitus). British Journal of Medical and Health Research, 10(2), 1-9. https://doi.org/10.5281/zenodo.7690636.
Ikwuka, A. O. (2023)e. Dr. Aloy’s Core Essential Series (DACES) Hematology. 1st Edition. Science and Education Publishing, USA, p. 27. ISBN: 978-1-958293-09-6.
Ikwuka, A. O., Omoju, D. I., & Mahanera, O. K. (2023)f. Profiling of Clinical Dynamics of Type 2 Diabetes Mellitus in Patients: A Perspective Review. World Journal of Current Medical and Pharmaceutical Research, 5(5), 210-218. https://doi.org/10.37022/wjcmpr.v5i5.294.
Institute of Health Metrics and Evaluation. (2022). Global Health Data Exchange (GHDx). Available online: vizhub.healthdata.org/gbd-results/
Javaid, A., Mehreen, S., Khan, M.A., Ashiq, N., Ihtesham, M., Khan, A., Ullah, I., & Basit, A. (2017). Depression and its associated factors with multidrug-resistant tuberculosis at baseline. Journal of Depression and Anxiety, 6(1), 253-258.
Kroenke, K., Spitzer, R. L., & Williams, J. B. (2002). The PHQ-9: validity of a brief depression severity measure. Journal of General and Internal Medicine, 16(9), 606-613.
Larson, E. H., Moverman, H. Y., Saito, S., Frederix, K., Pitt, B., Maama-Maime, L., & Howard, A. A. (2017). Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho. International Journal of Tuberculosis and Lung Diseases, 21(11), S34–S41.
Molla, A., Mekuriaw, B., & Kerebih, H. (2019). Depression and associated factors among patients with tuberculosis in Ethiopia: a cross-sectional study. Neuropsychiatric Diseases and Treatment, 8(15), 1887–1893.
Musa, S., Ikwuka, A. O., Udeh, F. C., Musa, A. A., & Chukwuezie, U. C. (2023). CRISPR-Cas9 Genomic Editing as an Innovation in the Management of Sickle Cell Disease: A Systematic Review. American Journal of Medical Science and Innovation, 2(2), 36-48. https://doi.org/10.54536/ajmsi.v2i2.1760.
National Institute of Mental Health. (2021). Depression. Available online: https://www.nimh.nih.gov/sites/default/files/documents/health/publications/depression/21-mh-8079-depression_0.pdf
Okeke, G. C., Okeke, I. K., Ikwuka, A. O., & Udeh, F. C. (2023)a. COVID-19 Vaccination in Pregnancy: Acceptance and Challenges amongst Pregnant Women in Adena, North-Central Nigeria. World Journal of Preventive Medicine, 11(1), 1-9. https://doi.org/10.12691/jpm-11-1-1.
Okeke, G. C., Okeke, I. K., Ikwuka, A. O., & Udeh, F. C. (2023)b. Knowledge, Perception and Acceptance of COVID-19 Vaccination Amongst Pregnant Women in Adena, Kwara State, Nigeria. World Journal of Public Health, 8(2), 165-174. https://doi.org/10.11648/j.wjph.20230802.29.
Pederson, C. B., Mors, O., Bertelsen, A., Waltoft, B. L., Agerbo, E., NcGrath, J. J., Mortensen, P. B., & Eaton W. W. (2014). A comprehensive nationwide study of incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry, 71(5), 573-581.
Salodia, U. P., Sethi, S., & Khokhar, A. (2019). Depression among tuberculosis patients attending a DOTS centre in a rural area of Delhi: A cross-sectional study. Indian Journal of Public Health, 63, 39-43.
Udeh, F. C., Ikwuka, A. O., Epete, M. A., & Igwe, E. C. (2023)a. Effects of Local Tobacco Snuff Ingestion during Pregnancy on Renal Functions and Histology Architecture of Female Wistar Rats and on the Birth Weight of Their Pups. American Journal of Medical Sciences and Medicine, 11(1), 1-5. https://doi.org/10.12691/ajmsm-11-1-1.
Udeh, F. C., Ikwuka, A. O., Epete, M. A., & Igwe, E. C. (2023)b. Effects of Oral Consumption of Nicotiana Tabacum During Pregnancy on the Liver and Prolactin Levels of Adult Female Wistar Rats. European Journal of Veterinary Medicine, 3(2), 1-5. https://doi.org/10.24018/ejvetmed.2023.3.2.93.
Udeh, F. C., Ikwuka, A. O., Nwandu, T. C., Ewunonu, E. O., Egwu, O. A., Ezinwa, G. A., & Anaetor, I. S. C. (2023)c. Human Anatomy Education: Knowledge, attitude, perception and challenges encountered by medical and nursing students in two Gambian Universities. Journal of Tertiary Education and Learning, 1(3), 29-38. https://doi.org/10.54536/jtel.v1i3.2277.
Virstyuk, N. G., Ikwuka, A. O., Haman, I. O., & Adebomi, M. S. (2016). Diabetes mellitus type 2, arterial hypertension and dyslipidemia. Materials of 2nd International Scientific and Practical Conference “Therapeutic readings: modern aspects of diagnosis and treatment of diseases of internal organs”, p. 46-47.
Virstyuk, N. G., & Ikwuka, A. O. (2017)a. Diagnostic and prognostic markers of the diabetes mellitus type 2 course in connection with essential arterial hypertension taking into account the kidney function. Precarpathian Journal Pulse, 8(44), 53-62.
Virstyuk, N. H., Ikwuka, A. O., Losyuk, L. V., Kobrynska, O. Ya., & Markiv, H. D. (2017)b. Dapagliflozin utility in patients with diabetes mellitus type 2 and essential hypertensive disease. Actual Problems of Modern Medicine, 4(60)1, 76-79. Available online: http://www.umsa.edu.ua/journal2stat4_2017_eng.html
Virstyuk, N. G., & Ikwuka, A. O. (2018)a. Features of asymptomatic hyperuricemia in patients with diabetes mellitus type 2 and concomitant essential arterial hypertension. Clinical and Experimental Pathology, 1(63), 22-26. https://doi.org/10.24061/1727-4338.XVII.1.63.2018.5.
Virstyuk, N. G., Ikwuka, A. O., & Didushko, O. M. (2018)b. Effect of dapagliflozin on the level of uric acid during asymptomatic hyperuricemia in patients with diabetes mellitus type 2 and concomitant arterial hypertension. Art of Medicine, 1(5), 21-26. Available online: https://art-of-medicine.ifnmu.edu.ua/index.php/aom/article/view/179/150
Virstyuk, N. H., & Ikwuka, A. O. (2018)c. Dapagliflozin influence on the clinical course of diabetes mellitus type 2 and essential hypertension in patients. Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions, p. 2007-2008. https://doi.org/10.1007/978-3-319-70548-4_582.
Virstyuk, N. G., & Ikwuka, A. O. (2019). Nephropathic characteristics in patients with diabetes mellitus type 2 and essential hypertensive disease. Art of Medicine, 1(5), 44-47. https://doi.org/10.21802/artm.2019.1.9.44.
Virstyuk, N. G., & Ikwuka, A. O. (2021)a. Asymptomatic hyperuricemia and functional state of the kidneys in patients with essential arterial hypertension and concomitant diabetes mellitus type 2. European Journal of Clinical Medicine, 2(3), 100-104. https://doi.org/10.24018/clinicmed.2021.2.3.65.
Virstyuk, N. H., Ikwuka, A. O., Luchko, O. R., & Kocherzhat, O. I. (2021)b. Peculiarities of renal insufficiency in patients with diabetes mellitus type 2 and arterial hypertension. Materials of scientific-practical conference with international participation “Achievements and prospects of experimental and clinical endocrinology” Twentieth Danilevsky readings, p. 86-87.
World Health Organization. (2022). Mental Health and COVID-19: Early evidence of the pandemic’s impact. WHO Scientific Brief. Geneva.
World Health Organization. (2023)a. Global Tuberculosis Report 2023. WHO. Available online: http://www.who.int/tb/publications/global_report/en/
World Health Organization. (2023)b. Osun State not taking its foot off the pedal in the fight against tuberculosis. WHO Africa.
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