Oral Acyclovir Induced Acute Kidney Injury
DOI:
https://doi.org/10.54536/ajcp.v1i2.829Keywords:
Oral Acyclovir, Acute Kidney Injury, Acyclovir Nephrotoxicity, MedicineAbstract
Acyclovir is an antiviral medication often used to treat outbreaks of herpes in children. Acyclovir has an exceptional safety profile; there is a possibility that it might induce severe nephrotoxicity in rare cases. In this report, we present the case of a 17-year-old girl with acute renal injury as a side effect of using acyclovir. The patient was admitted for three days due to drug-induced AKI, which was reversed by discontinuing the afflicted medicine (acyclovir), initiating appropriate hydration with intravenous normal saline 0.9%, and refraining from any nephrotoxic medications. Following up a week later, the patient was asymptomatic and had normal kidney function. Therefore, it is critical to use acyclovir correctly to avoid possibly fatal consequences.
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References
Balfour H. H., J. (1984). Intravenous acyclovir therapy for varicella in immunocompromised children. . The Journal of pediatrics, 104(1), 134-136. https://doi.org/ https://doi.org/10.1016/s0022-3476(84)80611-3
Brigden, D., Rosling, A. E., & Woods, N. C. (1982). Renal function after acyclovir intravenous injection. The American journal of medicine, 73(1), 182-185.
Chawla, L., Bellomo, R., Bihorac, A. et al. . (2017). Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nat Rev Nephrol 13, 241-257. https://doi.org/https://doi.org/10.1038/nrneph.2017.2.
Gunness P, A. K., Koren G. (2010). The effect of acyclovir on the tubular secretion of creatinine in vitro. J Transl Med., 30(8), 139. https://doi.org/10.1186/1479-5876-8-139
Izzedine, H., Launay-Vacher, V., & Deray, G. (2005). Antiviral drug-induced nephrotoxicity. American journal of kidney diseases : the official journal of the National Kidney Foundation, 45(5), 807-817. https://doi.org/ https://doi.org/10.1053/j.ajkd.2005.02.010
Mason, W. J., & Nickols, H. H. . (2008). Images in clinical medicine. Crystalluria from acyclovir use. The New England journal of medicine, 358(13). https://doi.org/ https://doi.org/10.1056/NEJMicm066726 (14)
Perazella., M. A. (1999). Crystal-induced acute renal failure. American Journal of Medicine, 106(4), 459-465.
Ratan., P. K. S. a. S. K. (2003). A case of chronic renal dysfunction following treatment with oral acyclovir. Scandinavian Journal of Infectious Diseases, 35(10), 770-772.
Sawyer, M. H., Webb, D. E., Balow, J. E., & Straus, S. E. (1988). Acyclovir-induced renal failure: clinical course and histology. The American journal of medicine, 84(6), 1067-1071.
Wade JC, M. J. (1983). Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med, 98, 921-925.
Yildiz C, O. Y., Gucer S, Cengiz AB, Topaloglu R. (2013). Acute kidney injury due to acyclovir. CEN Case Rep, 1, 38-40. https://doi.org/10.1007/s13730-012-0035-0
YY., B. (1984). The use of acyclovir in children. Pediatric infectious disease, 3(4), 575-578. https://doi.org/https://doi.org/10.1097/00006454-198407000-00017
Zhang Y, C. Y., Teng Y. (2016). Acute renal injury induced by valacyclovir hydrochloride: A case report. Exp Ther Med, 6, 4025-4028. https://doi.org/10.3892/etm.2016.3905.
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Copyright (c) 2023 Yasser Sadawey, Yasameen Abdulhameed
This work is licensed under a Creative Commons Attribution 4.0 International License.
