A Clinical Profile Observational Study in a Tertiary Care Hospital of Children with Atopic Dermatitis

Authors

  • Naveen Divakaran Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
  • Cherian Joseph Little Flower Hospital, Angamaly, Kerala, India

DOI:

https://doi.org/10.54536/ajmsi.v4i1.3401

Keywords:

Atopic Dermatitis, Children’s Health, Observational Study, Pediatrics, Precipitating Factors

Abstract

Atopic dermatitis, which is simply referred to as eczema, is a common persistent skin condition that impacts children and infants across the globe, accounting for 10-30% of them. Extreme itching, skin swelling, infections, and additional itching characterize it. There has been a rise in the incidence of the disease in the last 30 years primarily due to the effluent environment, breastfeeding, increased prevalence and awareness of the disease, and urbanization. The present study aimed to describe the clinical aspects of children diagnosed with atopic dermatitis, fulfilling the Hanifin and Rajka clinical criteria, visiting outpatient clinics of pediatrics and dermatology. Also, the study had a specific objective of identifying the possible factors that could worsen atopic dermatitis among the participants in the study. This trial covered 59 kids with atopic dermatitis; they filled questionnaires concerning their age, sex, complaints, things that worsen their condition, age of disease onset, and related symptoms. The other explored history included dietary one, breastfeeding history and the family or individual atopic history. A clinical assessment was carried out comprising localization and type of lesions and other features. It was revealed that females experience more atopic dermatitis than males and most of the children are affected from an early age. Food intolerance was the most common reason reported, with milk as the most frequent substance, followed by wool and lipid solvents. Half of the patients showed aggravation during the cold season. Dermatitic lesions involved the face and flexural areas more compared with the limbs. We found that 30 percent of the patients took complementary therapies, while 30 percent were malnourished. This work examined 59 children with atopic dermatitis ranging from 2 months to 12 years. It found that females were more affected than males, with an M: F ratio of 0.84:1. The most common manifestation experienced by the patients was purpuritus which was worse at night in about one-third of the population. Recurrence during the particular season was noticeable in half of the patients. Facial rash and flexural areas of extremities were found to be more affected by dermatitic lesions.

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References

Aggithaya, M. G., Narayana, P. P., Prasanna, K., & Narahari, S. (2021). Prevalence of atopic disorders in 10–15 years age group students from Kasaragod district, Kerala: A cross-sectional study. Clinical Epidemiology and Global Health, 12, 100823.

Ailawadi, P., Pal, V., Singal, A., & Pandhi, D. (2024). Impact of atopic dermatitis on quality of life in children and their families: A tertiary care hospital-based study from Northern India. Indian Journal of Skin Allergy, 3(1), 54–59.

Akhmedova, M., & Akhmedova, D. (2021). Clinical features and risk factors for the development of atopic bronchial asthma combined with allergic rhinosinusitis in children. ACADEMICIA: An International Multidisciplinary Research Journal, 11(9), 1015–1020.

Al-Adawiyah, R., Putera, A. M., Astari, L., & Ariyanto, F. C. (2021). Determinant factors of recurrence atopic dermatitis symptoms in children: A cross-sectional study. Annals of Medicine and Surgery, 70, 102847.

Alexander, H., Paller, A., Traidl-Hoffmann, C., Beck, L., De Benedetto, A., Dhar, S., Girolomoni, G., Irvine, A., Spuls, P., & Su, J. (2020). The role of bacterial skin infections in atopic dermatitis: Expert statement and review from the International Eczema Council Skin Infection Group. British Journal of Dermatology, 182(6), 1331–1342.

Barbarot, S., Silverberg, J. I., Gadkari, A., Simpson, E. L., Weidinger, S., Mina-Osorio, P., Rossi, A. B., Brignoli, L., Mnif, T., & Guillemin, I. (2022). The family impact of atopic dermatitis in the pediatric population: Results from an international cross-sectional study. The Journal of Pediatrics, 246, 220–226.e225.

Becerril-Ángeles, M., Vargas, M. H., Medina-Reyes, I. S., & Rascón-Pacheco, R. A. (2023). Trends (2007–2019) of major atopic diseases throughout the life span in a large Mexican population. World Allergy Organization Journal, 16(1), 100732.

Belzer, A., & Parker, E. R. (2023). Climate change, skin health, and dermatologic disease: A guide for the dermatologist. American Journal of Clinical Dermatology, 24(4), 577–593.

Bieber, T. (2022). Atopic dermatitis: An expanding therapeutic pipeline for a complex disease. Nature Reviews Drug Discovery, 21(1), 21–40.

Bocheva, G. S., Slominski, R. M., & Slominski, A. T. (2021). Immunological aspects of skin aging in atopic dermatitis. International Journal of Molecular Sciences, 22(11), 5729.

Bylund, S., von Kobyletzki, L. B., Svalstedt, M., & Svensson, Å. (2020). Prevalence and incidence of atopic dermatitis: A systematic review. Acta Dermato-Venereologica, 100(12).

Chovatiya, R. (2023). Atopic dermatitis (eczema). JAMA, 329(3), 268.

Dierick, B. J., van der Molen, T., Flokstra-de Blok, B. M., Muraro, A., Postma, M. J., Kocks, J. W., & van Boven, J. F. (2020). Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis, and food allergy. Expert Review of Pharmacoeconomics & Outcomes Research, 20(5), 437–453.

Domínguez, O., Plaza, A. M., & Alvaro, M. (2020). Relationship between atopic dermatitis and food allergy. Current Pediatric Reviews, 16(2), 115–122.

Dreno, B., Amici, J. M., Demessant-Flavigny, A. L., Wright, C., Taieb, C., Desai, S. R., & Alexis, A. (2021). The impact of acne, atopic dermatitis, skin toxicities, and scars on quality of life and the importance of a holistic treatment approach. Clinical, Cosmetic and Investigational Dermatology, 623–632.

Ezzedine, K., Shourick, J., Merhand, S., Sampogna, F., & Taieb, C. (2020). Impact of atopic dermatitis in adolescents and their parents: A French study. Acta Dermato-Venereologica, 100(17).

Faye, O., Flohr, C., Kabashima, K., Ma, L., Paller, A. S., Rapelanoro, F. R., Steinhoff, M., Su, J. C., Takaoka, R., & Wollenberg, A. (2024). Atopic dermatitis: A global health perspective. Journal of the European Academy of Dermatology and Venereology, 38(5), 801–811.

Frazier, W., & Bhardwaj, N. (2020). Atopic dermatitis: Diagnosis and treatment. American Family Physician, 101(10), 590–598.

Hadi, H. A., Tarmizi, A. I., Khalid, K. A., Gajdács, M., Aslam, A., & Jamshed, S. (2021). The epidemiology and global burden of atopic dermatitis: A narrative review. Life, 11(9), 936.

Hartmane, I. (2024). Study of genetic mutations and their association with the development of atopic dermatitis and other skin diseases. Plastic and Aesthetic Nursing, 44(3), 200–209.

Hui-Beckman, J. W., Goleva, E., Leung, D. Y., & Kim, B. E. (2023). The impact of temperature on the skin barrier and atopic dermatitis. Annals of Allergy, Asthma & Immunology.

Jaros, J., Wilson, C., & Shi, V. Y. (2020). Fabric selection in atopic dermatitis: An evidence-based review. American Journal of Clinical Dermatology, 21, 467–482.

Liao, M., Su, J., Li, J., Tao, J., Kang, X., Wu, B., Shan, S., Wang, X., Chen, X., & Xiao, Y. (2022). Consumption of red meat and atopic dermatitis: A cross-sectional study in Chinese college students. Dermatitis, 33(4), e48–e51.

Lin, B., Dai, R., Lu, L., Fan, X., & Yu, Y. (2020). Breastfeeding and atopic dermatitis risk: A systematic review and meta-analysis of prospective cohort studies. Dermatology, 236(4), 345–360.

Maksimovic, N., Zaric, M., Reljic, V., Nikolic, M., & Gazibara, T. (2020). Factors associated with improvement of quality of life among parents of children with atopic dermatitis: 1‐year prospective cohort study. Journal of the European Academy of Dermatology and Venereology, 34(2), 325–332.

Mehta, Y., & Fulmali, D. G. (2022). Relationship between atopic dermatitis and food allergy in children. Cureus, 14(12).

Mocanu, M., Vâță, D., Alexa, A.-I., Trandafir, L., Patrașcu, A.-I., Hâncu, M. F., & Gheucă-Solovăstru, L. (2021). Atopic dermatitis—beyond the skin. Diagnostics, 11(9), 1553.

Napolitano, M., Fabbrocini, G., Martora, F., Genco, L., Noto, M., & Patruno, C. (2022). Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication. Dermatologic Therapy, 35(12), e15901.

Nath, S., Kumari, N., Bandyopadhyay, D., Sinha, N., Majumder, P. P., Mitra, R., & Mukherjee, S. (2020). Dysbiotic lesional microbiome with filaggrin missense variants associate with atopic dermatitis in India. Frontiers in Cellular and Infection Microbiology, 10, 570423.

Papapostolou, N., Xepapadaki, P., Gregoriou, S., & Makris, M. (2022). Atopic dermatitis and food allergy: A complex interplay—what we know and what we would like to learn. Journal of Clinical Medicine, 11(14), 4232.

Parthasarathy, N., Palit, A., Inamadar, A. C., & Adya, K. A. (2020). A study to estimate the frequency of Hanifin and Rajka’s minor criteria in children for diagnosis of atopic dermatitis in a tertiary care center in South India. Indian Journal of Paediatric Dermatology, 21(1), 31–35.

Podder, I., Agarwall, K., & Anurag, A. (2022). Pattern and distribution of pediatric dermatoses and their association with parental socioeconomic status: A single-center experience from India. Indian Journal of Paediatric Dermatology, 23(3), 214–220.

Ramírez-Marín, H. A., Singh, A. M., Ong, P. Y., & Silverberg, J. I. (2022). Food allergy testing in atopic dermatitis. JAAD International, 9, 50–56.

Rustad, A. M., Nickles, M. A., Bilimoria, S. N., & Lio, P. A. (2022). The role of diet modification in atopic dermatitis: Navigating the complexity. American Journal of Clinical Dermatology, 1–10.

Sekita, A., Kawasaki, H., Fukushima-Nomura, A., Yashiro, K., Tanese, K., Toshima, S., Ashizaki, K., Miyai, T., Yazaki, J., & Kobayashi, A. (2023). Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis. Nature Communications, 14(1), 6133.

Siegels, D., Heratizadeh, A., Abraham, S., Binnmyr, J., Brockow, K., Irvine, A. D., Halken, S., Mortz, C. G., Flohr, C., & Schmid-Grendelmeier, P. (2021). Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis. Allergy, 76(4), 1053–1076.

Srinivas, S. M., Dhar, S., Gowdra, A., Saha, A., Sundararajan, L., Geetha, T. S., Banerjee, R., Malakar, R., Sil, A., & Prasad, A. L. S. (2023). Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study. Indian Journal of Dermatology, Venereology and Leprology, 89(6), 819–827.

Trikamjee, T., Comberiati, P., D’Auria, E., Peroni, D., & Zuccotti, G. V. (2021). Nutritional factors in the prevention of atopic dermatitis in children. Frontiers in Pediatrics, 8, 577413.

Wang, S. P., Stefanovic, N., Orfali, R. L., Aoki, V., Brown, S. J., Dhar, S., Eichenfield, L. F., Flohr, C., Ha, A., & Mora, C. (2024). Impact of climate change on atopic dermatitis: A review by the International Eczema Council. Allergy, 79(6), 1455–1469.

Wollenberg, A., Werfel, T., Ring, J., Ott, H., Gieler, U., & Weidinger, S. (2023). Atopic dermatitis in children and adults: Diagnosis and treatment. Deutsches Ärzteblatt International, 120(13), 224.

Yoo, J., Koo, H. Y. R., Han, K., & Lee, Y. B. (2022). Impairment of quality of life and mental health status in adult-onset atopic dermatitis. Annals of Dermatology, 34(4), 278.

Zhao, J., Zhang, Z., Chen, H., Dou, X., Zhao, Z., Liu, L., Wang, Y., & Li, H. (2023). Association of demographic characteristics, aggravating factors, comorbidities, and treatments with atopic dermatitis severity. Authorea Preprints.

Published

2025-04-23

How to Cite

Divakaran, N., & Joseph, C. (2025). A Clinical Profile Observational Study in a Tertiary Care Hospital of Children with Atopic Dermatitis. American Journal of Medical Science and Innovation, 4(1), 102–112. https://doi.org/10.54536/ajmsi.v4i1.3401