A Systematic Review on Infertility in Men Due to Sperm DNA Damage: Causes Investigations, & Management


  • Muna Rashed Al Khaldi Department of Medicine and Surgery, Cairo University, Egypt
  • Manal Al-khaldi Department of Medicine, King Hamad University Hospital, Al Sayh, Bahrain




Dna Damage, Infertility, Oxidative Stress, Sperm, Sexual Intercourse


The prevalence of sperm DNA damage is common in infertile men, caused by several factors. This systematic review aims to conclude causative agents, advanced and effective diagnostic aids, and treatment plans. After a critical review of 1123 articles and research papers collected from Google Scholar, Pub-Med, the Database of Abstracts of Reviews of Effects, Embase, PsycINFO, Ovid Medline, and Cochrane Central Register of Controlled Trials, 14 reviews have been included in this systemic review according to PRISMA guidelines. Included studies describe sufficiently regarding cause, investigations and management of infertility in men caused by sperm DNA damage. According to the results, 14 reviews have been eligible for this systemic review. The subject of these reviews is associated with sperm DNA damage in men, causing infertility. These reviews summarised Oxidative stress as one of the major causative factors. Different diagnostic tools have advantages, making them suitable for the scenario. It summarises that the factors affecting male infertility are general worldwide. This review could provide fundamental strategic plans dealing with specific risk factors and managing accordingly.


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How to Cite

Al Khaldi, M. R., & Al-khaldi, M. (2023). A Systematic Review on Infertility in Men Due to Sperm DNA Damage: Causes Investigations, & Management. American Journal of Medical Science and Innovation, 2(2), 79–89. https://doi.org/10.54536/ajmsi.v2i2.1967