Artificial Intelligence-Based Computer-Aided Diagnosis of Neonatal Sepsis: CurrentAdvances, Challenges and Clinical Opportunities in Nigeria

Authors

  • Charity S. Odeyemi Department of Computer Engineering, School of Electrical Systems Engineering, Federal University of Technology, Akure, Nigeria
  • Brendan C. Ubochi Department of Electrical Electronics Engineering, School of Electrical Systems Engineering, Federal University of Technology Akure, Nigeria
  • Adekemi J. Olowu Department of Computer Engineering, School of Electrical Systems Engineering, Federal University of Technology, Akure, Nigeria
  • Wailu O. Apena Department of Computer Engineering, School of Electrical Systems Engineering, Federal University of Technology, Akure, Nigeria

DOI:

https://doi.org/10.54536/ajdsai.v2i2.7798

Keywords:

Artificial Intelligence, Computer-Aided Diagnosis, Machine learning, Mortality, Neonatal Healthcare, Sepsis

Abstract

The mortality rate of neonatal sepsis in Nigeria ranges from 26.7% to 33.3% because of the low accuracy of the available methods of diagnosis, owing to its nonspecific symptoms. Also, the long time required (48 to 72 hours) to complete laboratory tests using common diagnostic tools, such as blood cultures and biomarkers. These challenges often lead to delayed treatment of infected babies and, eventually, high mortality rates. This article presents a review focusing on the potential of Artificial Intelligence-Based Computer-Aided Diagnosis (AI-CAD) systems for early diagnosis and treatment of neonatal sepsis. Specifically, the paper discusses traditional diagnostic methods for neonatal sepsis and their limitations. In addition, artificial intelligence methods such as machine learning, artificial neural networks, Random Forest, XGBoost, Support Vector Machine, and Long Short-Term Memory were studied as potential diagnostic tools for neonatal sepsis prediction. The paper presents a conceptual proposal for an AI-CAD system and the evaluation metrics for it. Such metrics include the F1-Score, area under the precision-recall curve (AUPRC), and the area under the receiver operating characteristic curve (AUROC), which could distinguish true positives from false positives at a baseline of 0.5. The review highlights the capabilities of AI-CAD systems to revolutionize neonatal healthcare in developing countries, improving diagnostics and reducing infant mortality rates. Nonetheless, the successful incorporation of such technologies requires addressing several important considerations, including the development of an electronic medical database, ethical issues, and Medical-Tech (MediTech) professionals’ collaborations.

Author Biographies

  • Charity S. Odeyemi, Department of Computer Engineering, School of Electrical Systems Engineering, Federal University of Technology, Akure, Nigeria

    Senior Lecturer, Artificial Intelligence and Smart systems in the Department of Computer Engineering Federal University of Technology Akure

  • Brendan C. Ubochi, Department of Electrical Electronics Engineering, School of Electrical Systems Engineering, Federal University of Technology Akure, Nigeria

    Associate Professor of Electronics and Communication Engineering at the Federal University of Technology Akure Nigeria

  • Adekemi J. Olowu, Department of Computer Engineering, School of Electrical Systems Engineering, Federal University of Technology, Akure, Nigeria

    PhD student at the Department of Computer Engineering, Federal University of Technology Akure

  • Wailu O. Apena, Department of Computer Engineering, School of Electrical Systems Engineering, Federal University of Technology, Akure, Nigeria

    A professor Biomedical Computing at the Department of Computer Engineering Federal University of Technology Akure, Nigeria

References

Adedokun, A. A., Onosakponome, E. O., & Nyenke, C. U. (2020). Early Onset and Late Onset of Neonatal Sepsis in a Tertiary Hospital, South-South, Nigeria. Journal of Advances in Microbiology, 20(6), 19–29. https://doi.org/10.9734/jamb/2020/v20i630249

Agarwal, R., & Kainth, D. (2025). Artificial intelligence in neonatal sepsis: Scope, challenges, and potential solutions! Seminars in Fetal and Neonatal Medicine, 31(1), 101687–101687. https://doi.org/10.1016/j.siny.2025.101687

Agnche, Z., Yenus Yeshita, H., & Abdela Gonete, K. (2020). Neonatal sepsis and its associated factors among neonates admitted to neonatal intensive care units in primary hospitals in Central Gondar Zone, Northwest Ethiopia, 2019. Infection and Drug Resistance, 13, 3957–3967. https://doi.org/10.2147/idr.s276678

Ahmed, A. M., Mohammed, A. T., Bastawy, S., Attalla, H. A., Yousef, A. A., Abdelrazek, M. S., Fransawy Alkomos, M., & Ghareeb, A. (2019). Serum Biomarkers for the Early Detection of the Early-Onset Neonatal Sepsis. Advances in Neonatal Care, 19(5), E26–E32. https://doi.org/10.1097/anc.0000000000000631

Cantey, J. B., & Lee, J. H. (2021). Biomarkers for the Diagnosis of Neonatal Sepsis. Clinics in Perinatology, 48(2), 215–227. https://doi.org/10.1016/j.clp.2021.03.012

Celik, I. H., Hanna, M., Canpolat, F. E., & Pammi, M. (2021). Diagnosis of neonatal sepsis: the past, present and future. Pediatric Research, 91(2), 337–350. https://doi.org/10.1038/s41390-021-01696-z

Charikleia Kariniotaki, Thomou, C., Despoina Gkentzi, Eleftherios Panteris, Dimitriou, G., & Eleftheria Hatzidaki. (2024). Neonatal Sepsis: A Comprehensive Review. Antibiotics, 14(1), 6–6. https://doi.org/10.3390/antibiotics14010006.

Cherima, Y. J., Enebeli, U. U., Kalu, E. I., Amadi, A. N., Kalu, F. A., Igwe, P. C., Kalu, J. J., & Kalu, B. O. (2026). Digital transformation of mental health care: A strategic framework for Nigeria’s federal neuropsychiatric hospitals. American Journal of Data Science and Artificial Intelligence, 2(1), 15–21. https://doi.org/10.54536/ajdsai.v2i1.6669

Domenico U. D, R., Maria Paola Ronchetti, Martini, L., Jole R., Iannetta, M., Dotta, A., & Cinzia A. (2024). Diagnosis and Management of Neonatal Bacterial Sepsis: Current Challenges and Future Perspectives. Tropical Medicine and Infectious Disease, 9(9), 199–199. https://doi.org/10.3390/tropicalmed9090199

Du, L.Z. (2024). Early diagnosis and management of neonatal sepsis: A perspective. World Journal of Pediatrics, 20. https://doi.org/10.1007/s12519-024-00803-4

Eichberger, J., Resch, E., & Resch, B. (2022). Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers. Frontiers in Pediatrics, 10(840288). https://doi.org/10.3389/fped.2022.840288

Gojak, Dž., Gvožđar, K., Hećimović, Z., Smajović, A., Bečić, E., Deumić, A., Bećirović, L. S., Pokvić, L. G., & Badnjević, A. (2022). The use of artificial intelligence in the diagnosis of neonatal sepsis. IFAC-PapersOnLine, 55(4), 62–67. https://doi.org/10.1016/j.ifacol.2022.06.010.

Hall, K. K., Shoemaker, H. S., & Hoffman, L. (2020). Diagnostic errors. In K. K. Hall, H. S. Shoemaker, & L. Hoffman (Eds.), Making healthcare safer III: A critical analysis of existing and emerging patient safety practices. Agency for Healthcare Research and Quality. https://www.ncbi.nlm.nih.gov/books/NBK555525

Helguera-Repetto, A. C., Soto-Ramírez, M. D., Villavicencio-Carrisoza, O., Yong-Mendoza, S., Yong-Mendoza, A., León-Juárez, M., González-y-Merchand, J. A., Zaga-Clavellina, V., & Irles, C. (2020). Neonatal Sepsis Diagnosis Decision-Making Based on Artificial Neural Networks. Frontiers in Pediatrics, 8(525). https://doi.org/10.3389/fped.2020.00525

Honoré, A., Forsberg, D., Adolphson, K., Chatterjee, S., Jost, K., & Herlenius, E. (2023). Vital sign‐based detection of sepsis in neonates using machine learning. Acta Paediatrica, 112(4), 686–696. https://doi.org/10.1111/apa.16660

Kim, F., Polin, R. A., & Hooven, T. A. (2020). Neonatal sepsis. BMJ, 371(371). https://doi.org/10.1136/bmj.m3672

Klingenberg, C., Kornelisse, R. F., Buonocore, G., Maier, R. F., & Stocker, M. (2018). Culture-Negative Early-Onset Neonatal Sepsis — At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship. Frontiers in Pediatrics, 6. https://doi.org/10.3389/fped.2018.00285

Lyra, S., Jin, J., Leonhardt, S., & Lüken, M. (2023). Early prediction of neonatal sepsis from synthetic clinical data using machine learning. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 1–4). IEEE. https://doi.org/10.1109/EMBC40787.2023.10341082

Narasimha Rao, K. V. K. L., Dadabada, P. K., & Jaipuria, S. (2024). A systematic literature review of predictive analytics methods for early diagnosis of neonatal sepsis. Discover Public Health, 21(1). https://doi.org/10.1186/s12982-024-00219-5.

Ngolah, K. T., Vivient, K., Kamla, & Elie, F. (2024). Machine learning techniques for the management of diseases: A paper review. In Safe, secure, ethical, responsible technologies and emerging applications (pp. 361–379). Springer. https://doi.org/10.1007/978-3-031-56396-6_23

Nyenga, A. M., Mukuku, O., & Wembonyama, S. O. (2021). Neonatal sepsis: A review of the literature. Theory and Clinical Practice in Pediatrics, 3(1), 94–101. https://doi.org/10.25082/tcpp.2021.01.006

Odabasi, I. O., & Bulbul, A. (2020). Neonatal Sepsis. The Medical Bulletin of Sisli Etfal Hospital, 54(2), 142–158. https://doi.org/10.14744/SEMB.2020.00236.

Odeyemi C. S, Olaniyan O. M., Sobowale A. A & Samuel I B. (2024): Artificial Intelligence (AI) Based Techniques for Reducing Neonatal Mortality in Nigeria: A Descriptive Review. UNIOSUN Journal of Engineering and Environmental Science (UNIOSUNJEET) 6(2) 86-94

Odeyemi, C. S., & Olaniyan, O. M. (2026). A proposed machine learning-driven framework for multi-disease classification in neonatal morbidity prediction using LSTM networks in Nigeria. International Journal of Engineering and Information Systems, 10(2), 1–6. https://www.ijeais.org/ijeais

Ogbara, C., Chime, H., & Nwose, E. (2021). Neonatal Sepsis in Nigeria 1: Introductory Overview. Biomedical Journal of Scientific & Technical Research, 36(2). https://doi.org/10.26717/bjstr.2021.36.005814.

Procianoy, R. S., & Silveira, R. C. (2020). The challenges of neonatal sepsis management. Jornal de Pediatria, 96(1), 80–86. https://doi.org/10.1016/j.jped.2019.10.004

Rainio Oona, Teuho jarmo and Klen Riku (2024): Evaluation Metrics and statistical Test for Machine learning. Scientific Report 14, 6086 (2024). https://doi.org/10.1038/s41598-024-56706-x.

Sheikh, A., & Rinvee, T. M. (2025). Data Analytics and Artificial Intelligence in Smart Healthcare Logistics: Building Resilient and Sustainable Systems. American Journal of Data Science and Artificial Intelligence, 1(2), 26-30. https://doi.org/10.54536/ajdsai.v1i2.6024.

Sullivan, B. A., Kausch, S. L., & Fairchild, K. D. (2022). Artificial and human intelligence for early identification of neonatal sepsis. Pediatric Research, 93(4887). https://doi.org/10.1038/s41390-022-02274-7

Van, O. M., Ingmar I. P., Loohuis, V., Jeroen D., Manon B., Richard B., & Daniel V. (2023). Development and clinical impact assessment of a machine-learning model for early prediction of late-onset sepsis. Computers in Biology and Medicine, 163(107156), 107156–107156. https://doi.org/10.1016/j.compbiomed.2023.107156

Yohanes, G. R., & Tilahun, M. S. (2023). Neonatal disease prediction using machine learning techniques. Journal of Healthcare Engineering, 2023, 3567194. https://doi.org/10.1155/2023/3567194

Downloads

Published

2026-09-09

How to Cite

Odeyemi, C. S. ., Ubochi, B. C. ., Olowu, A. J. ., & Apena, W. O. . (2026). Artificial Intelligence-Based Computer-Aided Diagnosis of Neonatal Sepsis: CurrentAdvances, Challenges and Clinical Opportunities in Nigeria. American Journal of Data Science and Artificial Intelligence, 2(2), 46-53. https://doi.org/10.54536/ajdsai.v2i2.7798

Similar Articles

1-10 of 20

You may also start an advanced similarity search for this article.