Does the COVID-19 Vaccines Effect on the Menstrual Cycle, Cross-Sectional Study Among Adult Females at King Saud University
DOI:
https://doi.org/10.54536/ajmri.v3i6.3091Keywords:
COVID-19 vaccine, Contraceptive Pills, Menstrual Cycle, Oligomenorrhea, Polycystic OvarieSAbstract
COVID-19 vaccinations have been associated with irregularities in the menstrual cycle and symptoms occurring pre and post-menstruation, affecting women’s reproductive health. This study aimed to demonstrate the impact of COVID-19 vaccines on women’s reproductive health by examining the association between COVID-19 vaccines and disturbed menstrual cycles. This cross-sectional survey-based study was conducted among adult females at King Saud University, Saudi Arabia, from April 2022 to August 2022. A total of 380 participants were selected through a stratified random sampling technique. Ethical approval was obtained from the Deanship of Scientific Research at King Saud University. The data were analysed using descriptive statistics and appropriate statistical tests. The results revealed that 53.9% of the participants experienced disturbances in the menstrual cycle after receiving the COVID-19 vaccination. Adult females aged 18-25 showed the highest rate of disorders. Menstrual disruptions were substantially correlated with marital status (p = 0.05), with a significant association between the number of COVID-19 vaccine doses and the occurrence of menstrual disturbances (p = 0.001). The administration of the vaccination during menstruation was linked to a notable occurrence of menstrual disturbances, although the p-value showed no statistical significance. A significant correlation was examined (p < 0.05) between pre-existing menstrual problems and the occurrence of disorders after receiving the COVID-19 vaccine (p < 0.05). The study emphasised the importance of tailored healthcare treatments for women following COVID-19 vaccination and the need for regular evaluation of reproductive health outcomes post-COVID-19 vaccination.
Downloads
References
Al Kadri, H. M., Al Sudairy, A. A., Alangari, A. S., Al Khateeb, B. F., & El-Metwally, A. A. (2023). COVID-19 vaccination and menstrual disorders among women: Findings from a meta-analysis study. Journal of Infection and Public Health.
Alaamri, O., Okmi, E. A., & Suliman, Y. (2022). Vaccine hesitancy in Saudi Arabia: A cross-sectional study. Tropical Medicine and Infectious Disease, 7(4), 60.
Alahmadi, A. M., Aljohani, A. H., Fadhloun, R. A., Almohammadi, A. S., Alharbi, D. F., Alrefai, L. S., Fadhloun, R., Almohammadi, A., & Alharbi, D. (2022). The effect of the COVID-19 vaccine on the menstrual cycle among reproductive-aged females in Saudi Arabia. Cureus, 14(12).
Alahmari, A. M., & Rahman, S. K. a. E. (2022). Relationship between menstrual cycle changes and types of covid-19 vaccines among women living in Riyadh, Saudi Arabia 2022. Medical Science, 26(126), 1–9. https://doi.org/10.54905/disssi/v26i126/ms340e2306
Alghamdi, A. N., Alotaibi, M. I., Alqahtani, A. S., Al Aboud, D., & Abdel-Moneim, A. S. (2021). BNT162b2 and ChAdOx1 SARS-CoV-2 post-vaccination side-effects among Saudi vaccinees. Frontiers in Medicine, 8, 760047.
Alhazmi, A., Alamer, E., Daws, D., Hakami, M., Darraj, M., Abdelwahab, S., Maghfuri, A., & Algaissi, A. (2021). Evaluation of side effects associated with COVID-19 vaccines in Saudi Arabia. Vaccines, 9(6), 674.
ALHUR, A. A. (2023). Public Health Informatics: The Importance of Covid-19 Dashboard in KSA for Sharing and Visualizing Health Information. Journal of Information Systems and Digital Technologies, 5(1), 43-59.
Almousa, I. A. (2022). Changes In the Menstrual Cycle Among the Covid-19 Vaccinated Women in The Eastern Province of Saudi Arabia: A Cross-Sectional Survey, 2022. The Egyptian Journal of Hospital Medicine, 89(1), 4260-4264.
Alvergne, A., Kountourides, G., Argentieri, M. A., Agyen, L., Rogers, N., Knight, D., Sharp, G. C., Maybin, J. A., & Olszewska, Z. (2021). COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study. medRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2021.11.23.21266709
Alvergne, A., Woon, E. V., & Male, V. (2022). Effect of COVID-19 vaccination on the timing and flow of menstrual periods in two cohorts. Frontiers in reproductive health, 4.
Barbieri, R. L. (2014). The endocrinology of the menstrual cycle. Human fertility: methods and protocols, 145-169.
Beatty, A. L., Peyser, N. D., Butcher, X. E., Cocohoba, J. M., Lin, F., Olgin, J. E., Pletcher, M. J., & Marcus, G. M. (2021). Analysis of COVID-19 vaccine type and adverse effects following vaccination. JAMA network open, 4(12), e2140364-e2140364.
Berga, S. L. (2020). The Menstrual Cycle and Related Disorders. Female Reproductive Dysfunction, 23-37.
Bull, J. R., Rowland, S. P., Scherwitzl, E. B., Scherwitzl, R., Danielsson, K. G., & Harper, J. (2019). Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles. NPJ digital medicine, 2(1), 83.
About V-Safe. (2024, August 8). Vaccine Safety Systems. https://www.cdc.gov/vaccine-safety-systems/v-safe/index.html
Chao, M. J., Menon, C., & Elgendi, M. (2022). Effect of COVID-19 vaccination on the menstrual cycle. Frontiers in Medicine, 9, 1065421.
Critchley, H. O., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J. Y. J., Lavender, M., & Marsh, E. E. (2020). Menstruation: science and society. American journal of obstetrics and gynecology, 223(5), 624-664.
De Sanctis, V., Bernasconi, S., Bianchin, L., Bona, G., Bozzola, M., Buzi, F., De Sanctis, C., Rigon, F., Tatò, L., & Tonini, G. (2014). Onset of menstrual cycle and menses features among secondary school girls in Italy: A questionnaire study on 3,783 students. Indian journal of endocrinology and metabolism, 18(Suppl 1), S84.
Demir, O., Sal, H., & Comba, C. (2021). Triangle of COVID, anxiety and menstrual cycle. Journal of Obstetrics and Gynaecology, 41(8), 1257-1261.
Farland, L. V., Khan, S. M., Shilen, A., Heslin, K. M., Ishimwe, P., Allen, A. M., Herbst-Kralovetz, M. M., Mahnert, N. D., Pogreba-Brown, K., & Ernst, K. C. (2023). COVID-19 vaccination and changes in the menstrual cycle among vaccinated persons. Fertility and sterility, 119(3), 392-400.
Gibson, E. A., Li, H., Fruh, V., Gabra, M., Asokan, G., Jukic, A. M. Z., Baird, D. D., Curry, C. L., Fischer-Colbrie, T., & Onnela, J. P. (2022). Covid-19 vaccination and menstrual cycle length in the Apple Women’s Health Study. NPJ digital medicine, 5(1), 165.
Gopaul, C. D., Bassaw, B., Ventour, D., & Thomas, D. (2023). Effects of Covid-19 vaccines on the menstrual cycle: A cross-sectional study. The Open Public Health Journal, 16(1).
Gray, S. H. (2013). Menstrual disorders. Pediatrics in review, 34(1), 6-18.
Hatmal, M. M., Al-Hatamleh, M. a. I., Olaimat, A. N., Hatmal, M., Alhaj-Qasem, D. M., Olaimat, T. M., & Mohamud, R. (2021). Side effects and perceptions following COVID-19 vaccination in Jordan: A randomized, Cross-Sectional study implementing machine learning for predicting severity of side effects. Vaccines, 9(6), 556. https://doi.org/10.3390/vaccines9060556
Huhmann, K. (2020). Menses requires energy: A review of how disordered eating, excessive exercise, and high stress lead to menstrual irregularities. Clinical Therapeutics, 42(3), 401-407.
Jung, E. K., Kim, S. W., Ock, S. M., Jung, K. I., & Song, C. H. (2018). Prevalence and related factors of irregular menstrual cycles in Korean women: The 5th Korean National Health and Nutrition Examination Survey (KNHANES-V, 2010–2012). Journal of Psychosomatic Obstetrics & Gynecology, 39(3), 196-202.
Kumar, N., Gangane, N., Mohapatra, I., Rukadikar, C., Sharmila, V., Pushpalatha, K., Eerike, M., Santhoshi, G., Samantaray, S. R., Seth, S., Trigunait, P., Reddy, N. J., Patel, S., Rani, S., Mishra, R., & Negi, K. (2023). Effect of COVID-19 vaccination on menstrual cycle patterns of reproductiveage women: a multi-centric observational study. Current Drug Research Reviews, 16(2), 237–248. https://doi.org/10.2174/2589977515666230608140606
Li, K., Chen, G., Hou, H., Liao, Q., Chen, J., Bai, H., Lee, S., Wang, C., Li, H., & Cheng, L. (2021). Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reproductive biomedicine online, 42(1), 260-267.
Male, V. (2021). Menstrual changes after covid-19 vaccination. BMJ, n2211. https://doi.org/10.1136/bmj.n2211
Moreira Jr, E. D., Kitchin, N., Xu, X., Dychter, S. S., Lockhart, S., Gurtman, A., Perez, J. L., Zerbini, C., Dever, M. E., & Jennings, T. W. (2022). Safety and efficacy of a third dose of BNT162b2 Covid-19 vaccine. New England journal of medicine, 386(20), 1910-1921.
Muhaidat, N., Alshrouf, M. A., Azzam, M. I., Karam, A. M., Al-Nazer, M. W., & Al-Ani, A. (2022). Menstrual symptoms after COVID-19 vaccine: a cross-sectional investigation in the MENA region. International journal of women’s health, 395-404.
Murray, C. M., & Orr, C. J. (2019). Hormonal regulation of the menstrual cycle and ovulation. In Elsevier eBooks (pp. 159–167). https://doi.org/10.1016/b978-0-12-814823-5.00012-x
World Health Organization: WHO. (2021, July 9). COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety (GACVS): updated guidance regarding myocarditis and pericarditis reported with COVID-19 mRNA vaccines. In. https://www.who.int/news/item/09-07-2021-gacvs-guidance-myocarditis-pericarditis-covid-19-mrna-vaccines
Patricio, B.-P., & Sergio, B.-G. (2019). Normal menstrual cycle. Menstrual Cycle, 15.
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., & Zerbini, C. (2020). Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New England journal of medicine, 383(27), 2603-2615.
Qashqari, F. S., Dahlawi, M., Assaggaf, H. M., Alsafi, R., Gari, A., Abudawood, A., Al-Doboke, A., Alsulami, S., Bukhari, R., & Majeed, S. A. (2022). Effect of the COVID-19 vaccine on the menstrual cycle among females in Saudi Arabia. Ethiopian journal of health sciences, 32(6).
Reed, B. G., & Carr, B. R. (2018, August 5). The normal menstrual cycle and the control of ovulation. Endotext - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK279054/
Roos, E. J., Simms-Cendan, J., Cheung, C., Laufer, D., & Grover, S. R. (2021). Pediatric and adolescent gynecology through a global lens. International Journal of Gynecology & Obstetrics, 156(2), 189–196. https://doi.org/10.1002/ijgo.13723
Saleh Alzahrani, H., Ali Algashami, S., Abdulaziz Alharkan, A., Sultan Alotaibi, N., & Waseem Algahs, N. (2023). The effect of COVID-19 vaccination on the menstrual cycle in female in Riyadh, Saudi Arabia. Saudi Pharmaceutical Journal, 31(5), 746-751. https://doi.org/https://doi.org/10.1016/j.jsps.2023.03.015
Schmalenberger, K. M., Tauseef, H. A., Barone, J. C., Owens, S. A., Lieberman, L., Jarczok, M. N., Girdler, S. S., Kiesner, J., Ditzen, B., & Eisenlohr-Moul, T. A. (2020). How to study the menstrual cycle: Practical tools and recommendations. Psychoneuroendocrinology, 123, 104895. https://doi.org/10.1016/j.psyneuen.2020.104895
Schmalenberger, K. M., Tauseef, H. A., Barone, J. C., Owens, S. A., Lieberman, L., Jarczok, M. N., Girdler, S. S., Kiesner, J., Ditzen, B., & Eisenlohr-Moul, T. A. (2021). How to study the menstrual cycle: Practical tools and recommendations. Psychoneuroendocrinology, 123, 104895. https://doi.org/https://doi.org/10.1016/j.psyneuen.2020.104895
Sualeh, M., Uddin, M. R., Junaid, N., Khan, M., Pario, A., & Ain, Q. (2022). Impact of COVID-19 Vaccination on Menstrual Cycle: A Cross-Sectional Study From Karachi, Pakistan. Cureus, 14(8).
Taşkaldıran, I., Vuraloğlu, E., Bozkuş, Y., İyidir, Ö. T., Nar, A., & Tütüncü, N. B. (2022). Menstrual Changes after COVID-19 Infection and COVID-19 Vaccination. International Journal of Clinical Practice, 2022, 1–5. https://doi.org/10.1155/2022/3199758
Tayyaba Rehan, S., Imran, L., Mansoor, H., Sayyeda, Q., Hussain, H. u., Cheema, M. S., Tahir, M. J., Asghar, M. S., Mahmmoud Fadelallah Eljack, M., & Islam, M. S. (2022). Effects of SARS-CoV-2 infection and COVID-19 pandemic on menstrual health of women: A systematic review. Health Science Reports, 5(6), e881.
Thiyagarajan, D. K., Basit, H., & Jeanmonod, R. (2024, September 27). Physiology, menstrual cycle. StatPearls-NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK500020/
Trogstad, L., Juvet, L., Feiring, B., & Blix, K. (2022). Covid-19 vaccines and menstrual changes. BMJ medicine, 1(1).
Vladimirovna, S. V., Anvarovna, S. L., Vladimirovna, M. E., & Khidirovna, L. Z. (2023). Menstrual Cycle Disturbances in the Reproductive Period. Central Asian Journal of Medical and Natural Science, 4(2), 389-397.
Vogazianou, A. (2019). Anatomy and physiology of the female reproductive system. Advanced Practice in Endocrinology Nursing, 739-752.
Von Woon, E., & Male, V. (2022). Effect of COVID-19 vaccination on menstrual periods in a prospectively recruited cohort. medRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2022.03.30.22273165
Wei, S.-M., Schiller, C. E., Schmidt, P. J., & Rubinow, D. R. (2018). The role of ovarian steroids in affective disorders. Current opinion in behavioral sciences, 23, 103-112.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Taghread Saadi Alghamdi, Eltigani O. M. Omer

This work is licensed under a Creative Commons Attribution 4.0 International License.