Discovering Variability in Population of T-Lymphocyte Subsets Present in Peripheral Blood of Patients Co-Infected by HIV and HBV Through Laboratory Medicine
DOI:
https://doi.org/10.54536/ajmri.v3i5.3088Keywords:
CD+8 T- Cells, CD4+ T-Cells, CD8+ Cell Exhaustion, HIV/HBV Infection, Lymphocyte Subpopulations, Weak Immune SystemAbstract
An alarming number of 296 million individuals in Egypt have recently been diagnosed as HBV positive; because these two viruses share similar routes of transmission, about 10% of this population is also thought to be HIV positive. It is widely acknowledged that coinfection with HIV and HBV has a significant negative effect on the immune system and accelerates the loss of T-lymphocyte subpopulations, which are essential for immunological defense. This enlightening study, carried out in Cairo, Egypt, explores the complicated dynamics of T-cell subsets and carefully looks at the immunological effects and frequency of coinfection between HIV and HBV. Naturally, of the 35 patients in the cohort under examination, an impressive 8.4% had coinfections with HBV and HIV. Systematic immunophenotyping of several T-cell subsets, such as CD4+, CD8+, CD45RO, CD16+56, and CD45RA, was used in the study, and the results showed clear differences between coinfected and mono-infected peopleUsing trustworthy methods like microfluid inertial separation and flow cytometry has given researchers significant insights into the complex immunological circumstances connected to HIV/HBV coinfection. Interestingly, a significant decrease in CD4+ cells—a crucial marker of HIV progression—was observed in over 50% of the coinfected patients, suggesting an accelerated course of the illness in these individuals. Moreover, the study establishes the foundation for particular treatment strategies and adds to our scientific understanding coinfection dynamics. These therapies, based on the study’s detailed findings, can potentially improve patient outcomes despite this difficult coinfection setting. To manage the difficulties of HIV/HBV coinfection, the research emphasizes the importance of ongoing attention and the incorporation of cutting-edge diagnostic techniques, eventually advancing public health activities.
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