Template-Free Synthesis and Control Drug Release of Calcium Carbonate-Hydroxylapatite Composite
DOI:
https://doi.org/10.54536/ajmri.v1i2.248Keywords:
CO2-expanded carbonation, Hydroxylapatite, Composite, Drug delivery agent, Control releaseAbstract
We employed Gas expanded liquids (GXLs) technology to synthesize calcium carbonate-hydroxylapatite composite (CaCO3-HAp) nanoparticles and investigated the effects of reaction parameters on the properties of the composites as well as the performance of the composites as drug delivery agent using ibuprofen as a model drug in simulated gastric fluid. Separately, calcium carbonate and hydroxylapatite have been used extensively in pharmaceutical and drug delivery systems (DDS). However, both CaCO3 and HAp have individual draw-backs and limitations in applications. The results showed that the composite had good thermal stability and better surface area and pore (volume and size) properties. Studies on the performance of the composites as a drug delivery agent using ibuprofen as a model drug in simulated gastric fluid revealed that the composite promoted the dissolution of ibuprofen outstandingly. Whereas the low pressure loaded composite showed quicker relief potential (92% release) in 30 minutes with control release over desirable time frame (3h, 20 min), the high pressure loaded composite also exhibited quicker relief potential (80% release) in 30 minutes but with control release over remarkable time frame (6h, 40 min). The implication is that if a patient is administered with ibuprofen loaded into the synthesized composite at low pressure (10.0 MPa), the patient will experience quicker relief (92% release of ibuprofen) in 30 min and which will be sustained for almost 3.5 hours. Similarly, the high pressure (17.0 MPa) loaded ibuprofen will also provide a patient with quicker relief (80% release of ibuprofen) however, the relief in this case will be sustained for longer period; about 6.5 hours. Therefore, the high pressure loaded composite had tremendous effect on the control release of ibuprofen and can be used as effective drug delivery system (DDS) for drugs with similar characteristics.
Downloads
References
Aaron, M. S., Hutchenson, K., & Subramaniam, B. (2009). Gas-Expanded Liquids: Fundamentals and applications, in: Gas-Expanded Liquids and Near-Critical Media, American Chemical Society, Washington, DC, 3-37.
Akien, G. R., & Poliakoff, M. (2009). A Critical Look at Reactions in Class I and II Gas-Expanded Liquids Using CO2 and other Gases. Green Chemistry, 11, 1083-1100.
Chen, W. W., Hu, X. H., Hong, Y. Z., Su, Y. Z., Wang, H. T., & Li, J. (2013). Ibuprofen Nanoparticles Prepared by a PGSS™-Based Method. Powder Technology 45, 241–250.
Domingo, C., Loste, E., Gomez-Morales, J., Garcia-Carmona, J., & Fraile, J. (2006). Calcite Precipitation by a High-Pressure CO2 Carbonation Route. Journal of Supercritical Fluids, 36, 202-215
Eduardo da Silva, A. B., Costa, C. A. E., Vilar, V. J. P., Botelho, C. M. S., Larosi, M. B., Saracho, J. M. P., & Boaventura, R. A. R. (2012). Water Remediation Using Calcium Phosphate Derived from Marine Residues. Water, air, and soil pollution, 223, 989-1003
Goh, Y-.F., Shakir, I., & Hussain, R. (2013). Electrospun fibers for Tissue Engineering, Drug Delivery, and Wound Dressing. Journal of Material Science, 48, 3027–3054
Goldberg, M. A., Smirnov, V. V., Kutsev, S. V., Shibaev, T. V., Shvornev, L. I., Sergeev, N. S., Sviridov, I. K., & Barinov, S. M. (2010). Hydroxyapatite–Calcium Carbonate Ceramic Composite Materials. Inorganic Materials, 46, 1269–1273
Gomez-Villalba, L. S., Lopez-Arce, P., Alvarez de Buergo, M., & Fort, R. (2012). Atomic Defects and their Relationship to Aragonite-Calcite Transformation in Portlandite Nanocrystal Carbonation. Crystal Growth & Design, 12, 4844-4852
Guoa, Y-.P., Yao, Y-.B., Guo, Y-.J., & Ning, C-.Q. (2012). Hydrothermal Fabrication of Mesoporous Carbonated Hydroxyapatite Microspheres for a Drug Delivery System, Microporous and Mesoporous Materials 155, 245–251
Harja, M., Cimpeanu, C., & Bucur, R. D. (2012). The Influence of Hydrodynamic Conditions on The Synthesis of Ultra-Thin Calcium Carbonate, Journal of Food, Agriculture & Environment, 10, 1191-1195
Hui, P., Meena, S. L., Singh, G., Agarawal, R. D., & Prakash S. (2010). Synthesis of Hydroxyapatite Bio-Ceramic Powder by Hydrothermal Method. Journal of Minerals and Materials Characterization Engineering 9, 683-692
Ibrahim, A-R., Benoit, R., Suo, X., Li, X. Y., Huang, Y., Ma, G. F., & Li, J. (2019). Ultra-Fast Route to Synthesizing Biogenic Carbonate Hydroxyapatite: Consequence of a High-Pressure Solid-Solid Preparation Technique. Chemical Engineering & Processing: Process Intensification, 142, 107549
Ibrahim, A-R., Gong, Y., Hu, X. H., Hong, Y. Z., Su, Y. H., Wang, H. T., & Li, J. (2013). Solid-gas Carbonation Coupled with Solid Ionic Liquid for Synthesis of CaCO3. Performance, Polymorphic Control and Self-catalytic Kinetics. Industrial and Engineering Chemistry Research, 52, 9515−9524
Ibrahim, A-R., Zhang, X. L., Hong, Y. Z., Su, Y. H., Wang, H. T., & Li, J. (2014b) Instantaneous Solid-Liquid-Gas Carbonation of Ca(OH)2 and Chameleonic Phase Transformation in CO2 Expanded Solution. Crystal Growth & Design, 14, 2733−2741
Ibrahim, A-R., Zhou, Y., Li, X. Y., Chen, L., Hong, Y. Z., Su, Y. Z., Wang, H. T., & Li, J. (2015). Synthesis of rod-like hydroxyapatite with high surface area and pore volume from eggshells for effective adsorption of aqueous Pb (II). Materials Research Bulletin, 62, 132–141
Ibrahim, A-R., Zhu, L, H., Xu, J., Hong, Y. Z., Su, Y. H., Wang, H. T., Chen, B. H., & Li, J. (2014a). Synthesis of Mesoporous Alumina with CO2-Expanded Carbonation and its Catalytic Oxidation of Cyclohexanone. Journal of Supercritical Fluids, 92, 190-196
Kim, I.-S., & Kumta, P.N. (2004). Sol-gel Synthesis and Characterization of Nanostructured Hydroxyapatite Powder. Material Science and Engineering B, 111, 232-236
Marloes. M. J. K., Angus P. R. J., Georgina K. S., Henk H. D., Richard A. E., Andrew M. S., Edouard C. N., Joan K. H., & Frank C., (2010). Targeting of cancer cells using click-functionalized polymer capsules, Journal of the American Chemical Society, 132, (45), 15881–15883
Montes-Hernandez, G., Daval, D., Chiriac, R., & Renard, F. (2010). Growth of Nanosized Calcite through Gas-Solid Carbonation of Nanosized Portlandite under Isobaric Conditions. Crystal Growth & Design 10, 4823-4830
Song, L., Chen, Y., Chen, K., Hu, X. H., & Li, J. (2017). Solute-Saturated Supercritical CO2 Loading of 2-Phenylethyl Alcohol in Silica and Activated Carbon: Measurement and Mechanism. The Journal of Supercritical Fluids 128, 378-385
Sopyan, I. (2004). Proceedings of the 3rd Annual Conference of the Asia Pacific Nanotechnology Forum. Shanghai, China, 180–188
Sun, Y., Chen, X-.Y., Zhu, Y-J., Liu, P-F., Zhu, M-J., & Duan, Y-R. (2012). Synthesis of Calcium Phosphate/GPC-mPEG Hybrid Porous Nanospheres for Drug Delivery to Overcome Multidrug Resistance in Human Breast Cancer. Journal of Materials Chemistry, 22, 5128-5136
Ueno, Y., Futagawa, H., Takagi, Y., Ueno, A., & Mizushima, Y. (2005). Drug Incorporating Calcium Carbonate Nanoparticles for a New Delivery System, Journal of Controlled Release, 103, 93-98
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Sulemana Yahaya, Tarlutu Ibrahim, Abdul-Rauf Ibrahim
This work is licensed under a Creative Commons Attribution 4.0 International License.
