The Role of CD64 and CRP in the Diagnosis of Sepsis in Neonates
DOI:
https://doi.org/10.54536/ajlsi.v4i1.4176Keywords:
CRP, Neonates, PCT, SepsisAbstract
Sepsis is the body’s extensive reaction to an infection. It is a severe medical emergency. Without prompt treatment, sepsis can quickly lead to tissue damage, organ failure, and death. Neonatal sepsis is defined as a syndrome of clinical features of the spread of infection and the presence of bacteremia increase access to the bloodstream. Bacteria most often cause infantile septicemia. An infant may be exposed to infections in the hospital or at home. This work came to assess the role of CRP and neutrophil CD64 in the diagnosis of sepsis in neonates and infants. This study is a case-control study, it involved two groups (60) patients and (20) controls of one day to one year of age during the period from May 2019 to September 2020 of neonates and infants admitted in Kerbala pediatric teaching hospital and Kerbala Primary health care centers. For a total of 80 children, two categories have been included and classified. the study showed the mean age for neonates of sepsis was (7.40±13) days while the mean age for neonates of control was (5.58±6.75)days, The mean age for infants of sepsis was (4.1±7.971) months while the mean age for infants of control was (4.01±5.66) months. in this research, CRP, PCT, and nCD64 are well-diagnostic biomarkers for early detection of neonatal and infantile sepsis. The combination of these biomarkers the diagnosis of suspected early and late-onset neonatal sepsis based on ROC curve analysis.
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Abdullah, Y. J., Kadhim, A. S., Khallaf, S. A., & Alsaedi, R. Z. J. (2021). Serum levels of interleukin–6, ferritin, C-reactive protein, lactate dehydrogenase, D-dimer and count of lymphocytes and neutrophils in COVID-19 patients. Its correlation to the disease severity. Annals of the Romanian Society for Cell Biology, 25(2), 2220-2228.
Adib, M., Bakhshiani, Z., Navaei, F., Fosoul, F. S., Fouladi, S., & Kazemzadeh, H. (2012). Procalcitonin: a reliable marker for the diagnosis of neonatal sepsis. Iranian journal of basic medical sciences, 15(2), 777.
Al-Karawi, A. S., & Kadhim, A. S. (2024). Exploring the role of autoantibodies in Iraqi females with polycystic ovary syndrome. J Adv Biotechnol Exp Ther, 2024(7), 147-56.
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
Bhandari, V., Wang, C., Rinder, C., & Rinder, H. (2008). Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics, 121(1), 129-134.
Edmond, K., & Zaidi, A. (2010). New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS medicine, 7(3), e1000213.
Greiner, M., Pfeiffer, D., & Smith, R. D. (2000). Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Preventive veterinary medicine, 45(1-2), 23-41.
Gupta, N., Kabra, M., & Kapoor, S. (2014). Establishing national neonatal perinatal database and birth defects registry network—Need of the hour!. Indian pediatrics, 51, 693-696.
Henderson, K. L., Johnson, A. P., Muller-Pebody, B., Charlett, A., Gilbert, R., & Sharland, M. (2010). The changing aetiology of paediatric bacteraemia in England and Wales, 1998–2007. Journal of medical microbiology, 59(2), 213-219.
Hornik, C. P., Fort, P., Clark, R. H., Watt, K., Benjamin Jr, D. K., Smith, P. B., ... & Cohen-Wolkowiez, M. (2012). Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early human development, 88, S69-S74.
Kadhim, A. S., Abdullah, Y. J., & Hasan, N. F. (2023). Asymptomatic individuals with coronavirus disease-19 as infectious cases and encouragement immunity hypothesis. Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2(2), 74-79.
Lawn, J. E., Kerber, K., Enweronu-Laryea, C., & Cousens, S. (2010, December). 3.6 million neonatal deaths—what is progressing and what is not?. In Seminars in perinatology (Vol. 34, No. 6, pp. 371-386). WB Saunders.
Levy, M. M., Artigas, A., Phillips, G. S., Rhodes, A., Beale, R., Osborn, T., ... & Dellinger, R. P. (2012). Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. The Lancet infectious diseases, 12(12), 919-924.
Moradi, N., Javadpoor, S., & Vahdani, M. (2015). Prevalence and antibiogram pattern of gram negative bacteria isolated from blood cultures in Shahid mohammadi hospital Bandar Abbas. Journal of Preventive Medicine, 2(2), 55-61.
Ng, P. C., Li, G., Chui, K. M., Chu, W. C., Li, K., Wong, R. P., ... & Fok, T. F. (2004). Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection. Pediatric research, 56(5), 796-803.
Sankar, M. J., Agarwal, R., Deorari, A. K., & Paul, V. K. (2008). Sepsis in the newborn. The Indian Journal of Pediatrics, 75, 261-266.
Sharma, A., Thakur, A., Bhardwaj, C., Kler, N., Garg, P., Singh, M., & Choudhury, S. (2020). Potential biomarkers for diagnosing neonatal sepsis. Current Medicine Research and Practice, 10(1), 12-17.
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., ... & Angus, D. C. (2016). The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama, 315(8), 801-810.
Vergnano, S., Sharland, M., Kazembe, P., Mwansambo, C., & Heath, P. T. (2005). Neonatal sepsis: an international perspective. Archives of Disease in Childhood-Fetal and Neonatal Edition, 90(3), F220-FF224.
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Copyright (c) 2025 Fatima Hakim Obaid, Kazem Mehdi Kazem, Israa Khudhair Obayes
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