Evaluating Tuberculosis Awareness and Screening Outcomes among Household Contacts of Index Cases: A Cross-Sectional Study in Ghana
DOI:
https://doi.org/10.54536/jir.v3i1.3949Keywords:
Awareness, Household Contacts, Index Case, Screening, TuberculosisAbstract
This study assessed TB prevalence and factors affecting screening among household contacts in Ga West Municipality, Ghana. A cross-sectional descriptive study was conducted with 107 household contacts of TB index cases identified from health facility records. A structured questionnaire collected data on demographics, TB knowledge, screening, and treatment status. Utilizing STATA 14, the statistical analysis included descriptive statistics and Pearson chi-square tests, with a significance level set at p < 0.05. The mean age of participants was 35.7 years (SD ± 11.8), predominantly male (58.9%) and urban dwellers (78.5%). Of the participants, 57.9% were screened for TB, with a positive rate of 20% (n=9). Among those diagnosed, 88.9% (n=8) initiated treatment. Awareness of TB was high (90.7%), yet only 6.7% could identify five key symptoms of TB. Significant associations were found between educational level and TB awareness (χ²(4) = 17.237, p = 0.002), between residence and screening likelihood (χ²(1) = 4.26, p = 0.039), and individuals residing within 5 km of a health facility had a higher likelihood of being screened compared to those living farther away (χ²(1) = 10.41, p = 0.001). This study found that despite high awareness of TB transmission, screening rates among household contacts were low; enhanced outreach and education efforts are needed to improve knowledge and screening, particularly for urban residents. The predominance of male pulmonary cases was noted, highlighting the necessity for targeted efforts to mitigate TB transmission and further research on barriers to screening.
References
Abdul, I. W., Ankamah, S., Iddrisu, A. K., & Danso, E. (2020). Space-time analysis and mapping of prevalence rate of tuberculosis in Ghana. Scientific African, 7, 1–10. https://doi.org/10.1016/j.sciaf.2020.e00307
Abu-humaidan, A. H. A., Tarazi, A., Hamadneh, Y., Al-leimon, A., Al-leimon, O., & Aljahalin, M. (2022). practices toward tuberculosis among Jordanian university students. Frontiers in Public Health, 10, 1–14. https://doi.org/10.3389/fpubh.2022.1055037
Afum, T., Asare, P., Asante-Poku, A., Darko-Otchere, I., Morgan, P. A., Bedeley, E., Asandem, D. A., Musah, A. B., Siam, I. M., Tetteh, P., Adusi-Poku, Y., Frimpong-Manso, R., Kofi Bonney, J. H., Ampofo, W., & Yeboah-Manu, D. (2021). Diagnosis of tuberculosis among COVID-19 suspected cases in Ghana. PLoS ONE, 16(12 December), 1–8. https://doi.org/10.1371/journal.pone.0261849
Almalki, M. E., Almuqati, F. S., Alasmari, R., Enani, M. J., Bahwirith, A. A., Alloqmani, A. A., Alqurashi, A., & Hassan-Hussein, A. (2022). A Cross-Sectional Study of Tuberculosis Knowledge, Attitude, and Practice Among the General Population in the Western Region of Saudi Arabia. Cureus, 14(10), 1–11. https://doi.org/10.7759/cureus.29987
Alsayed, S. S. R., & Gunosewoyo, H. (2023). Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets. International Journal of Molecular Sciences, 24(6), 1–23. https://doi.org/10.3390/ijms24065202
Angelo, A. T., Geltore, T. E., & Asega, T. (2020). Knowledge, attitude, and practices towards tuberculosis among clients visiting tepi general hospital outpatient departments, 2019. Infection and Drug Resistance, 13, 4559–4568. https://doi.org/10.2147/IDR.S287288
Artawan Eka Putra, I. W. G., Purnama Dewi, N. P. E., Probandari, A. N., Notobroto, H. B., & Wahyuni, C. (2023). The Implementation of Comprehensive Health Education to Improve Household Contacts’ Participation in Early Detection of Tuberculosis. Health Education and Behavior, 50(1), 136–143. https://doi.org/10.1177/10901981211001829
Biermann, O., Lönnroth, K., Caws, M., & Viney, K. (2019). Factors influencing active tuberculosis case-finding policy development and implementation: A scoping review. BMJ Open, 9(12), 1–12. https://doi.org/10.1136/bmjopen-2019-031284
Der, J. B., Grant, A. D., Grint, D., Narh, C. T., Bonsu, F., & Bond, V. (2022). Barriers to tuberculosis case finding in primary and secondary health facilities in Ghana: perceptions, experiences and practices of healthcare workers. BMC Health Services Research, 22(1), 1–14. https://doi.org/10.1186/s12913-022-07711-1
Dhanawade, S., Kumbhar, S., Gore, A., & Patil, V. (2015). Scar formation and tuberculin conversion following BCG vaccination in infants: A prospective cohort study. Journal of Family Medicine and Primary Care, 4(3), 384. https://doi.org/10.4103/2249-4863.161327
Dong, Z., Wang, Q. Q., Yu, S. C., Huang, F., Liu, J. J., Yao, H. Y., & Zhao, Y. L. (2022). Age period cohort analysis of pulmonary tuberculosis reported incidence, China, 2006 to 2020. Infectious Diseases of Poverty, 11(1), 1–10. https://doi.org/10.1186/s40249-022-01009-4
Ga West Health Directorate. (2016). Annual Report 2016.
Ghana Health Service. (2022). National Tuberculosis Control Programme. Ghana Health Service. https://ghs.gov.gh/national-tuberculosis-control-programme-ntp/
Guo, J., Yang, M., Wu, Z., Shen, X., Wang, Y., & Zhao, G. (2019). High incidence and low case detection rate among contacts of tuberculosis cases in Shanghai, China. BMC Infectious Diseases, 19(1), 1–10. https://doi.org/10.1186/s12879-019-3942-2
Humayun, M., Chirenda, J., Ye, W., Mukeredzi, I., Mujuru, H. A., & Yang, Z. (2022). Effect of Gender on Clinical Presentation of Tuberculosis (TB) and Age-Specific Risk of TB, and TB-Human Immunodeficiency Virus Coinfection. Open Forum Infectious Diseases, 9(10), 1–9. https://doi.org/10.1093/ofid/ofac512
Iddrisu, A., Amikiya, E. A., & Bukari, F. K. (2024). Spatio-temporal characteristics of Tuberculosis in Ghana. PUBMED Central, 111, 1–30. https://doi.org/10.12688%2Ff1000research.109053.4
Japan Anti-Tuberculosis Association. (2021). 52nd World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease. The International Journal of Tuberculosis and Lung Disease, 25(10), 1–477. https://jata.or.jp/english/
Jenkins, H. E., Ayuk, S., Puma, D., Brooks, M. B., Millones, A. K., Jimenez, J., Lecca, L., Galea, J. T., Becerra, M., Keshavjee, S., & Yuen, C. M. (2022). Geographic accessibility to health facilities predicts uptake of community-based tuberculosis screening in an urban setting. International Journal of Infectious Diseases, 120, 125–131. https://doi.org/10.1016/j.ijid.2022.04.031
Kazibwe, A., Twinomugisha, F., Musaazi, J., Nakaggwa, F., Lukanga, D., Aleu, P., Kiyemba, T., Nkolo, A., Kirirabwa, N. S., Freitas Lopez, D. B., Birabwa, E., Dejene, S., & Zawedde-Muyanja, S. (2021). Comparative yield of different active tb case finding interventions in a large urban tb project in central uganda: A descriptive study. African Health Sciences, 21(3), 975–984. https://doi.org/10.4314/ahs.v21i3.3
Kigozi, N. G., Heunis, J. C., Engelbrecht, M. C., Janse Van Rensburg, A. P., & Van Rensburg, H. C. J. D. (2017). Tuberculosis knowledge, attitudes and practices of patients at primary health care facilities in a South African metropolitan: Research towards improved health education. BMC Public Health, 17(1), 1–8. https://doi.org/10.1186/s12889-017-4825-3
Laghari, M., Azhar, S., Sulaiman, S., Khan, A. H., Talpur, B. A., & Bhatti, Z. (2019). Contact screening and risk factors for TB among the household contact of children with active TB : a way to find source case and new TB cases. BMC Public Health, 19(1274), 1–10. doi.org/10.1186/s12889-019-7597-0
Law, I., Floyd, K., Abukaraig, E. A. B., Addo, K. K., Adetifa, I., Alebachew, Z., Banda, R., Bashorun, A., Bloss, E., Bonsu, F. A., Chanda-Kapata, P., Demba, E., Elegail, A. M. A. S., Eltigany, M., Ershova, J., Gasana, M., Girma, B., Glaziou, P., Kalisvaart, N., … Yamada, N. (2020). National tuberculosis prevalence surveys in Africa, 2008–2016: an overview of results and lessons learned. Tropical Medicine and International Health, 25(11), 1308–1327. https://doi.org/10.1111/tmi.13485
Litvinjenko, S., Magwood, O., Wu, S., & Wei, X. (2023). Burden of tuberculosis among vulnerable populations worldwide: an overview of systematic reviews. The Lancet Infectious Diseases, 23(12), 1395–1407. https://doi.org/10.1016/S1473-3099(23)00372-9
MacNeil, A., Glaziou, P., Sismanidis, C., Date, A., Maloney, S., & Floyd, K. (2020). Global Epidemiology of Tuberculosis and Progress Toward Meeting Global Targets Worldwide, 2018. MMWR. Morbidity and Mortality Weekly Report, 69(11), 281–285. https://doi.org/10.15585/mmwr.mm6911a2
Martinez, L., Cords, O., Liu, Q., Acuna-Villaorduna, C., Bonnet, M., Fox, G. J., Carvalho, A. C. C., Chan, P. C., Croda, J., Hill, P. C., Lopez-Varela, E., Donkor, S., Fielding, K., Graham, S. M., Espinal, M. A., Kampmann, B., Reingold, A., Huerga, H., Villalba, J. A., … Andrews, J. R. (2022). Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. The Lancet Global Health, 10(9), e1307–e1316. https://doi.org/10.1016/S2214-109X(22)00283-2
Miller, P. B., Zalwango, S., Galiwango, R., Kakaire, R., Sekandi, J., Steinbaum, L., Drake, J. M., Whalen, C. C., & Kiwanuka, N. (2021). Association between tuberculosis in men and social network structure in Kampala, Uganda. BMC Infectious Diseases, 21(1), 1–9. https://doi.org/10.1186/s12879-021-06475-z
Ncayiyana, J. R., Bassett, J., West, N., Westreich, D., Musenge, E., Emch, M., Pettifor, A., Hanrahan, C. F., Schwartz, S. R., Sanne, I., & van Rie, A. (2016). Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: A cross-sectional study. BMC Infectious Diseases, 16(1), 1–10. https://doi.org/10.1186/s12879-016-1989-x
Ohene, S. A., Bonsu, F., Hanson-Nortey, N. N., Sackey, A., Danso, S., Afutu, F., Klatser, P., & Bakker, M. (2018). Yield of tuberculosis among household contacts of tuberculosis patients in Accra, Ghana. Infectious Diseases of Poverty, 7(1), 1–8. https://doi.org/10.1186/s40249-018-0396-5
Okoro, L. C., Odukoya, O., Ikwuka, A. O., & Udeh, F. C. (2024). Prevalence , Patterns and Peculiarities of Depression among Tuberculosis Patients Attending Directly Observed Treatment Short-course ( DOTS ) Centers in Lagos State Nigeria. American Journal of Medical Science and Innovation, 3(1), 62–72. https://doi.org/https://doi.org/10.54536/ajmsi.v3i1.2653
Olmo-Fontánez, A. M., & Turner, J. (2022). Tuberculosis in an Aging World. Pathogens, 11(10), 1–13. https://doi.org/10.3390/pathogens11101101
Onyango, V. C., Mutiso, B., Mutuma, N. M., Malalu, C. P., Auma, N., & Fryda, W. C. (2024). Miliary Tuberculosis Causing Presumed Primary Adrenal Insufficiency and Addisonian Crisis : A Case Report from Rural Kenya. American Journal of Medical Science and Innovation, 3(1), 91–95. https://doi.org/https://doi.org/10.54536/ajmsi.v3i1.2773
Quarcoopome, L., & Tornu, E. (2022). Health-related quality of life of persons living with tuberculosis: A cross-sectional study. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 28(June), 100324. https://doi.org/10.1016/j.jctube.2022.100324
Reichler, M. R., Khan, A., Yuan, Y., Chen, B., McAuley, J., Mangura, B., & Sterling, T. R. (2020). Duration of exposure among close contacts of patients with infectious tuberculosis and risk of latent tuberculosis infection. Clinical Infectious Diseases, 71(7), 1627–1634. https://doi.org/10.1093/cid/ciz1044
Ross, J. M., Xie, Y., Wang, Y., Collins, J. K., Horst, C., Doody, J. B., Lindstedt, P., Ledesma, J. R., Shapiro, A. E., Hay, P. S. I., Kyu, H. H., & Flaxman, A. D. (2021). Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis. EClinicalMedicine, 42, 1–7. https://doi.org/10.1016/j.eclinm.2021.101206
Ternaa, A., Elizabeth, A. U., & Sarc, T. (2022). Role of HIV Infection in Multi-Drug Resistant Tuberculosis in Parts of Benue State, Nigeria. American Journal of Medical Science and Innovation, 1(1), 1–9. https://doi.org/https://doi.org/10.54536/ajmsi.v1i1.505
Turusbekova, N., Celan, C., Caraulan, L., Rucsineanu, O., Jibuti, M., Ibragimova, O., & Saidova, N. (2022). Gender-related factors associated with delayed diagnosis of tuberculosis in Eastern Europe and Central Asia. BMC Public Health, 22(1), 1–9. https://doi.org/10.1186/s12889-022-14419-8
USAID. (2023). USAID’s global tuberculosis (TB) strategy 2023–2030. USAID. https://www.usaid.gov/global-health/health-areas/tuberculosis/resources/publications/usaid-global-tuberculosis-strategy-2023-2030
Vyambwera, S. M., & Witbooi, P. (2021). A Two-Group Model of TB in a Crowded Environment. Applied Mathematics and Information Sciences, 15(4), 523–532. https://doi.org/10.18576/amis/150415
World Health Organization. (2022). Global tuberculosis report 2022. https://iris.who.int/bitstream/handle/10665/363752/9789240061729-eng.pdf?sequence=1
World Health Organization. (2023). Tuberculosis. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/tuberculosis#:~:text=Worldwide%2C%20TB%20is%20the%20second,women%20and%201.3%20million%20children
Yayan, J., Franke, K. J., Berger, M., Windisch, W., & Rasche, K. (2024). Early detection of tuberculosis: a systematic review. Pneumonia, 16(1), 1–15. https://doi.org/10.1186/s41479-024-00133-z
Yousif, K., Ei Maki, M., Babikir, R. K., & Abuaisha, H. (2021). The effect of an educational intervention on awareness of various aspects of pulmonary tuberculosis in patients with the disease. Eastern Mediterranean Health Journal, 27(3), 287–292. https://doi.org/10.26719/emhj.20.102
Zhu, M., Han, G., Takiff, H. E., Wang, J., Ma, J., Zhang, M., & Liu, S. (2018). Times series analysis of age-specific tuberculosis at a rapid developing region in. Scientific Reports, 8(1), 2011–2016. https://doi.org/10.1038/s41598-018-27024-w
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Patrick Larbi-Debrah, Jonathan Mawutor Gmanyami, Amos Andoono, Richmond Bediako Nsiah, Dominic Nyarko, Obed Atsu-Ofori, Geoffrey Akungoe Ayambire, Shadrack Kyei, Isaac Morrison, Isaac Ayirebi, Lynna Naa Adede Obeng, Khadijatu Adiss Yusif, Enoch Nyarko, Isaac Owusu Mensah, Saida Abdul-Rahman Zakaria, Samuel Malogae Badiekang, Akua Kumi Yeboah, Frank Prempeh

This work is licensed under a Creative Commons Attribution 4.0 International License.