Insights into the Pathogenesis, Virulence Factors, and Diagnosis of Helicobacter pylori: A Comprehensive Review


  • Ali Saad Kadhim Department of science, Basic Education collage, Wasit University, Wasit, Iraq
  • Abdullah Salim Al-Karawi Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq



Helicobacter pylori, Endoscopy, PCR, Urea breath test, Serology test


The H. pylori bacterium, which resides in the human stomach and is linked to a number of gastrointestinal illnesses, is introduced in-depth in this article. We examine how H. pylori establishes infection, thwarts the hosting immune response, and causes inflammation as we explore the pathophysiology of this bacterium. We also talked about how H. pylori influences host cells and develops a favorable environment for survival. We also go over the many methods for identifying H. pylori, such as endoscopy, biopsy, blood, breath, feces, and others. We stress the importance of an accurate and speedy diagnosis while outlining the advantages and disadvantages of each diagnostic strategy to manage disorders caused by H. pylori effectively. Throughout this review, we aim to unravel the mysteries surrounding H. pylori, providing valuable insights into its pathogenesis, the intricate interplay of virulence factors, and the diverse diagnostic strategies employed in clinical practice. Enhancing our understanding of H. pylori can pave the way for improved therapies and patient outcomes.


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How to Cite

Kadhim , A. S., & Al-Karawi, A. S. (2023). Insights into the Pathogenesis, Virulence Factors, and Diagnosis of Helicobacter pylori: A Comprehensive Review. American Journal of Bioscience and Bioinformatics, 2(1), 31–37.