Preparation and Characterization of Zinc Oxide Nanoparticles by Co-Precipitation Method and Evaluation of Theirs Antifungal Activity in Spore Germination of Dermatophytes
DOI:
https://doi.org/10.54536/ajlsi.v3i2.3183Keywords:
Dermatophyte, Spore, Nanoparticle, ZnO, AntifungalAbstract
This research study synthesized Prepared zinc oxide nanoparticles using the co-precipitation method. The antifungal activities of these nanoparticles (ZnO NPs) and their mode of action against Trichophyton rubrum and Microsporum canis were investigated using samples obtained from patients referred to consulting clinics in Kirkuk city. These nano oxides were identified through XRD diffraction analysis, FTIR measurement, and Scanning Electron Microscopy (SEM). The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) values were recorded as 1.330 and 4.530 µg/mL for Trichophyton rubrum, and 0.333 and 10.67 μg/ml for Microsporum canis, respectively. The antifungal effect of (ZnO NPs) was similar to that of Griseofulvin, while it exhibited a higher effect than ketoconazole. Furthermore, (ZnO NPs) demonstrated a significant (P < 0.05) inhibition effect on spore germination for all tested dermatophytes, although the extent of this effect varied depending on the fungal isolates.
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